Summary
In-vitro and in-vivo studies have suggested a role for the adrenergic system in the
regulation of secretion of parathyroid hormone (PTH). In the present study the effects
of insulin induced hypoglycaemia on serum concentrations of PTH, cortisol, calcium
and phosphate were evaluated in ten healthy subjects.
Maximum hypoglycaemia occurred 25 to 35 min after administration of insulin at a standard
dose of 0.15 U/kg body weight. All this time there was a slight and transient increase
of the serum calcium concentrations whereas there was a marked drop in the serum phosphate
levels with a nadir 15 min after maximum hypoglycaemia. Cortisol levels were below
baseline when blood glucose was as lowest but increased to a maximum level of 200%
60 minutes after maximum hypoglycaemia.
Serum PTH levels increased significantly and reached a maximum of 130% of baseline
values concomitant with maximum hypoglycaemia, whereafter they returned to pre-insulin-injection
levels within 15 minutes. These findings indicate that during stress endogenous catecholamines
affect the secretion of PTH which could be of physiologic importance.
In five patients with primary hyperparathyroidism there was, however, no increase
in the PTH levels, although they displayed the same response to hypoglycaemia for
cortisol and phosphate. This supports previous suggestions that these patients have
an impaired capacity to respond to circulating catecholamines.
Key words
Parathyroid hormone - calcium - phosphate - catecholamines - hypoglycaemia - hyperparathyroidism
